Therapeutic effect of combination of alagebrium (ALT-711) and sildenafil on erectile function in diabetic rats
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چکیده
منابع مشابه
the effect of aqueous extract of garlic on formalin-induced pain in male rats
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15 صفحه اولFunctional Effects of Alagebrium (ALT-711)-Isolated Rat Carotid Artery.
Objective In our study, the effects of glycosylated protein cross-link breaker, alagebrium was investigated on isolated rat carotid artery using myography. Alagebrium showed vasodilator effect on carotid artery rings; particularly, this effect was significantly increased in endothelium-intact rings. Materials and Methods To clarify the vasodilator mechanism of alagebrium, different antagonist...
متن کاملPrevention and reversal of diabetic nephropathy in db/db mice treated with alagebrium (ALT-711).
BACKGROUND Alagebrium (ALT-711) has been shown to improve renal dysfunction in animal models of diabetes. METHODS To test its effects in diabetic nephropathy (DN), ALT-711 was administered (1 mg/kg daily i.p.) to 9-week-old female db/db mice (n = 15, group A1) for 3 weeks and to 3-month-old (n = 15, group A2), 7-month-old (n = 7, group A3), and 12-month-old (n = 5, group A4) female db/db mice...
متن کاملAB82. AGE-breaker ALT-711 plus insulin could restore erectile function in streptozocin-induced type 1 diabetic rats
INTRODUCTION The interaction between advanced glycation end-products (AGEs) and its receptors for AGEs (RAGEs) elicits oxidative stress and mediates the development of erectile dysfunction (ED). ALT-711, an AGE cross-link breaker, has the therapeutic potential for ED but has been less intensively investigated. AIM The aim of this study was to investigate the effects of an AGEs breaker 3-phena...
متن کاملstudy the effects of low level laser diode on no production and healing of diabetic and cortisone acetate and normal wounded sd rats
nitric oxide (no) is a small molecule synthesized by most of mammalian cells with diverse biological activities including vasodilatation, host defense and wound healing. impaired wound healing is a common occurrence among diabetics and patients receiving glucocorticoid therapy. on the other hand the application of laser in biomedical area have been increased. thus, the current studies were desi...
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ژورنال
عنوان ژورنال: International Journal of Impotence Research
سال: 2011
ISSN: 0955-9930,1476-5489
DOI: 10.1038/ijir.2011.54